Description

(S)-2-Isocyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, chiral building block essential for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its core value lies in the reactive isocyanate group and the protected pyrrolidine scaffold, which enable efficient, stereoselective construction of nitrogen-containing heterocycles. This compound is critically needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other bioactive molecules.
• Peptidomimetic Chemistry: Used to introduce constrained proline-like structures into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Agrochemical Research: Building block for novel pesticides and herbicides requiring specific stereochemistry.
• Chemical Biology Probes: Utilized in the development of activity-based probes for studying enzyme function.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule assembly.

Basic Information

Product Name	(S)-2-Isocyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1245908-97-7
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-(isocyanomethyl)pyrrolidine; (S)-N-Boc-2-(isocyanomethyl)pyrrolidine; (S)-2-Isocyanomethyl-1-(tert-butoxycarbonyl)pyrrolidine; tert-Butyl (S)-2-(isocyanomethyl)pyrrolidine-1-carboxylate; (S)-Boc-2-(isocyanomethyl)pyrrolidine; (S)-2-(Isocyanomethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine; (S)-1-Boc-2-(isocyanomethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-2-Isocyanomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and IR spectroscopy, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, this material should be stored in a cool, dry place, ideally at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.