Description

6-Bromo-1H-Pyrido[2,3-B][1,4]Oxazin-2(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, especially those targeting neurological disorders and cancer.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a key starting material (KSM) or intermediate in the scale-up and optimization of API manufacturing routes.
• Biochemical Research: Employed in the development of chemical probes and tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A foundational component for the custom synthesis of specialized compounds for preclinical and clinical studies.

Basic Information

Product Name	6-Bromo-1H-Pyrido[2,3-B][1,4]Oxazin-2(3H)-One
CAS No.	1245708-13-7
Molecular Formula	C7H5BrN2O2
Molecular Weight	229.03 g/mol
Synonyms	6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one; 6-Bromo-3,4-dihydro-1H-pyrido[2,3-b][1,4]oxazin-2-one; 6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-2-one; 6-Bromo-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one; 1245708-13-7; 6-Bromopyrido[2,3-b][1,4]oxazin-2(1H,3H,4H)-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-1H-Pyrido[2,3-B][1,4]Oxazin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.