Description

(S)-tert-Butyl 4-(2-(Benzyloxycarbonylamino)Propyl)Piperazine-1-Carboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a protected, stereochemically defined scaffold essential for constructing complex molecules with specific biological activity. This intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents.
• API Synthesis: Used in the multi-step synthesis of complex drug candidates, especially those containing piperazine and protected amine functionalities.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries and exploring structure-activity relationships (SAR).
• Peptidomimetic Development: Integral for creating peptide-like molecules with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (S)-configured propylamine side chain.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for cGMP production of clinical trial materials.

Basic Information

Product Name	(S)-tert-Butyl 4-(2-(Benzyloxycarbonylamino)Propyl)Piperazine-1-Carboxylate
CAS No.	1245649-99-3
Molecular Formula	C20H31N3O4
Molecular Weight	377.48 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-2-[(S)-1-[(tert-Butoxycarbonyl)piperazin-4-yl]propan-2-yl]hydrazine; (S)-1-Boc-4-(2-(Cbz-amino)propyl)piperazine; (S)-N-Cbz-1-Amino-2-(4-Boc-piperazin-1-yl)propane; tert-Butyl (S)-4-(2-((benzyloxy)carbonylamino)propyl)piperazine-1-carboxylate; (S)-Nα-Cbz-1,2-Diaminopropane Boc-Piperazine Derivative; Z-(S)-Amino-Pro-Boc-Piperazine; (S)-2-((Benzyloxycarbonyl)amino)-1-(4-(tert-butoxycarbonyl)piperazin-1-yl)propane
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 4-(2-(Benzyloxycarbonylamino)Propyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.