Description

1-(1-(4-(Trifluoromethyl)Phenyl)Cyclopropyl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropyl-piperazine scaffold combined with a trifluoromethylphenyl moiety. This compound matters for its critical role in modern medicinal chemistry, where it serves as a versatile building block for the synthesis of novel bioactive molecules, particularly in central nervous system (CNS) and oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this specialized intermediate to develop new drug candidates with potentially improved metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a privileged scaffold in structure-activity relationship (SAR) studies to optimize potency and selectivity.
• CNS Drug Development: Employed in the research of potential therapeutics for neurological and psychiatric disorders due to the piperazine moiety's prevalence in neuroactive compounds.
• Oncology Research: Serves as a building block for developing kinase inhibitors and other targeted cancer therapies.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents, leveraging the stability of the trifluoromethyl group.
• Chemical Biology Probe Synthesis: Utilized to create tool compounds for investigating biological targets and mechanisms of action.

Basic Information

Product Name	1-(1-(4-(Trifluoromethyl)Phenyl)Cyclopropyl)Piperazine
CAS No.	1245649-95-9
Molecular Formula	C14H17F3N2
Molecular Weight	270.29 g/mol
Synonyms	1-[1-[4-(Trifluoromethyl)phenyl]cyclopropyl]piperazine; 1-(1-(4-(Trifluoromethyl)phenyl)cyclopropyl)piperazine; 4-[1-[4-(Trifluoromethyl)phenyl]cyclopropyl]piperazine; 1245649-95-9; 1-(1-(p-Trifluoromethylphenyl)cyclopropyl)piperazine; 1-(1-(4-Trifluoromethylphenyl)cyclopropyl)piperazine; Piperazine, 1-[1-[4-(trifluoromethyl)phenyl]cyclopropyl]-
EINECS	Contact for details

Quality Control

Our 1-(1-(4-(Trifluoromethyl)Phenyl)Cyclopropyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.