Description

4-((4-Methylpiperazin-1-yl)Methyl)Picolinonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique piperazine-picolinonitrile hybrid structure. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors and other targeted therapeutics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial synthesis of protein kinase inhibitors and other small-molecule drug candidates.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Chemical Biology Probes: Serves as a precursor for developing tool compounds to study specific biological pathways and target validation.
• Process Chemistry Development: Employed in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and intermediate supply.

Basic Information

Product Name	4-((4-Methylpiperazin-1-yl)Methyl)Picolinonitrile
CAS No.	1245646-64-3
Molecular Formula	C12H16N4
Molecular Weight	216.28 g/mol
Synonyms	4-[(4-Methyl-1-piperazinyl)methyl]-2-pyridinecarbonitrile; 2-Cyano-4-[(4-methylpiperazin-1-yl)methyl]pyridine; 4-(4-Methylpiperazin-1-ylmethyl)picolinonitrile; 4-((4-Methylpiperazin-1-yl)methyl)picolinonitrile; 4-(4-Methylpiperazin-1-ylmethyl)-2-cyanopyridine; 2-Pyridinecarbonitrile, 4-[(4-methyl-1-piperazinyl)methyl]-; 1245646-64-3
EINECS	Contact for details

Quality Control

Our 4-((4-Methylpiperazin-1-yl)Methyl)Picolinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with customer specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.