Description

1-(1-(2-(Trifluoromethyl)Phenyl)Cyclopropyl)Piperazine is a high-value, advanced pharmaceutical intermediate featuring a unique cyclopropyl-piperazine scaffold substituted with a trifluoromethylphenyl group. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing complex molecular architectures with potential enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in neuropharmacology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Ligand and Probe Development: Serves as a core structure for developing chemical probes targeting specific enzymes or receptors in biological assays.
• Agrochemical Research: Intermediate in the development of new active ingredients with improved properties.
• Material Science: Potential precursor for specialty chemicals and advanced functional materials.

Basic Information

Product Name	1-(1-(2-(Trifluoromethyl)Phenyl)Cyclopropyl)Piperazine
CAS No.	1245646-33-6
Molecular Formula	C14H17F3N2
Molecular Weight	270.30 g/mol
Synonyms	1-[1-[2-(Trifluoromethyl)phenyl]cyclopropyl]piperazine; 1-(1-(2-(Trifluoromethyl)phenyl)cyclopropyl)piperazine; 1-(1-(o-Trifluoromethylphenyl)cyclopropyl)piperazine; 1-(1-(2-Trifluoromethylphenyl)cyclopropyl)piperazine; 1245646-33-6; Piperazine, 1-[1-[2-(trifluoromethyl)phenyl]cyclopropyl]-
EINECS	Contact for details

Quality Control

Our 1-(1-(2-(Trifluoromethyl)Phenyl)Cyclopropyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.