Description

2,5-Dibromo-3-Nitropyrazine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic positioning of bromine and nitro substituents on the pyrazine ring, which serve as versatile handles for further functionalization via cross-coupling and nucleophilic aromatic substitution reactions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting kinase inhibition or possessing other biologically active heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the pyrazine scaffold for bioactivity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Cross-Coupling Reactions: The bromine atoms are excellent substrates for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification.
• Nucleophilic Aromatic Substitution: The nitro group activates the pyrazine ring for substitution with various nucleophiles, facilitating the introduction of amines, alkoxides, and thiols.
• Chemical Library Development: Employed in combinatorial and medicinal chemistry for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	2,5-Dibromo-3-Nitropyrazine
CAS No.	1245645-88-8
Molecular Formula	C4H1Br2N3O2
Molecular Weight	282.87 g/mol
Synonyms	3-Nitro-2,5-dibromopyrazine; 2,5-Dibromo-3-nitropyrazine; Pyrazine, 2,5-dibromo-3-nitro-; 1245645-88-8; 2,5-Dibromo-3-nitro-pyrazine; Dibromonitropyrazine
EINECS	Contact for details

Quality Control

Our 2,5-Dibromo-3-Nitropyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment is to supply material that meets the exacting standards required for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.