Description

5-Chloro-3-Ethynylpyrazin-2-Amine is a high-purity, synthetically versatile pyrazine derivative featuring both chloro and ethynyl functional groups. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the construction of complex heterocyclic scaffolds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors, anticancer agents, and other small molecule therapeutics.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its reactive ethynyl group for click chemistry and palladium-catalyzed cross-coupling reactions.
• Agrochemical Development: Serves as a precursor in the research and development of new herbicides, fungicides, and plant growth regulators.
• Chemical Synthesis: Employed in organic synthesis to create complex pyrazine-based heterocycles and molecular libraries for high-throughput screening.
• Material Science: Potential use as a monomer or precursor in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	5-Chloro-3-Ethynylpyrazin-2-Amine
CAS No.	1244776-65-5
Molecular Formula	C6H4ClN3
Molecular Weight	153.57 g/mol
Synonyms	5-Chloro-3-ethynyl-2-pyrazinamine; 2-Amino-5-chloro-3-ethynylpyrazine; 3-Ethynyl-5-chloropyrazin-2-amine; 1244776-65-5; 5-Chloro-3-ethynylpyrazin-2-ylamine
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Ethynylpyrazin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.