Description

5-Chloro-3-((Trimethylsilyl)ethynyl)pyrazin-2-amine is a high-value, functionalized pyrazine derivative featuring both a chloro and a trimethylsilyl-protected ethynyl group. This unique structure makes it a versatile and critical advanced pharmaceutical intermediate for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as targeted drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialized polymers and organic electronic materials.
• Cross-Coupling Reactions: The chloro and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for introducing acetylene functionalities into lead compounds via deprotection.
• Chemical Synthesis: Acts as a versatile synthon for further functionalization to create libraries of pyrazine-based compounds for high-throughput screening.

Basic Information

Product Name	5-Chloro-3-((Trimethylsilyl)ethynyl)pyrazin-2-amine
CAS No.	1244776-64-4
Molecular Formula	C9H12ClN3Si
Molecular Weight	225.76 g/mol
Synonyms	2-Amino-5-chloro-3-[(trimethylsilyl)ethynyl]pyrazine; 5-Chloro-3-(2-trimethylsilylethynyl)pyrazin-2-amine; 5-Chloro-3-(trimethylsilylethynyl)-2-pyrazinamine; 2-Pyrazinamine, 5-chloro-3-[(trimethylsilyl)ethynyl]-; 5-Chloro-3-((trimethylsilyl)ethynyl)-2-aminopyrazine
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-3-((Trimethylsilyl)ethynyl)pyrazin-2-amine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.