Description

5-Fluoro-6-Morpholin-4-Yl-Pyridin-3-Ylamine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyridine core substituted with fluorine and morpholine functional groups. This compound matters for its critical role as a key building block in the synthesis of novel, targeted small-molecule therapeutics, particularly kinase inhibitors. Pharmaceutical R&D and process chemistry teams need it to develop and scale up next-generation drug candidates for oncology and other therapeutic areas. Its precise structure enables fine-tuning of drug potency, selectivity, and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitor programs.
• Oncology Drug Discovery: Serves as a core scaffold for developing novel anti-cancer agents targeting specific signaling pathways.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies to optimize lead compounds for efficacy and safety profiles.
• Process Development & Scale-up: Employed in pilot plant and commercial manufacturing to establish robust, GMP-compliant synthetic routes.
• Biochemical Tool Compound: Can be utilized in the development of probes and assays for biological target validation.
• Custom Synthesis: Acts as a starting material for contract research organizations (CROs) and CDMOs producing bespoke molecules for clients.

Basic Information

Product Name	5-Fluoro-6-Morpholin-4-Yl-Pyridin-3-Ylamine
CAS No.	1244642-62-3
Molecular Formula	C10H13FN4O
Molecular Weight	224.24 g/mol
Synonyms	3-Amino-5-fluoro-6-morpholinopyridine; 5-Fluoro-6-morpholinopyridin-3-amine; 6-Morpholino-5-fluoropyridin-3-amine; 5-Fluoro-6-morpholin-3-pyridinamine; 1244642-62-3; 5-Fluoro-6-morpholin-4-ylpyridin-3-amine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Morpholin-4-Yl-Pyridin-3-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.