Description

6-Cyclopropyl-4-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyridine class of heterocyclic compounds. Its molecular structure, featuring a cyclopropyl group and a trifluoromethyl moiety, makes it a critical building block for the synthesis of novel, biologically active molecules. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries. Its consistent quality and reliable supply are essential for accelerating drug discovery programs and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Kinase Inhibitor Development: Used in research for creating novel kinase inhibitors due to the privileged pyrazolopyridine scaffold.
• Agrochemical Research: Acts as a building block for developing new active ingredients in crop protection products.
• Chemical Biology: Employed in probe and tool compound synthesis for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	6-Cyclopropyl-4-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridin-3-Amine
CAS No.	1242267-90-8
Molecular Formula	C10H9F3N4
Molecular Weight	242.21 g/mol
Synonyms	6-Cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine; 3-Amino-6-cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridin-3-amine, 6-cyclopropyl-4-(trifluoromethyl)-; 1242267-90-8; 6-Cyclopropyl-4-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine; 6-Cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (ACI); 6-Cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine, 97%
EINECS	Contact for details

Quality Control

Our 6-Cyclopropyl-4-(Trifluoromethyl)-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.