Description

4-[(2,3-Dihydro-Benzo[1,4]Dioxine-2-Carbonyl)-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a protected piperidine scaffold essential for constructing molecules with targeted biological activity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly within the central nervous system and cardiovascular domains.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting GPCRs (G-protein coupled receptors).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• API Synthesis: Serves as a precursor in multi-step synthetic routes for the production of complex active pharmaceutical ingredients.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	4-[(2,3-Dihydro-Benzo[1,4]Dioxine-2-Carbonyl)-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1241231-81-1
Molecular Formula	C19H26N2O5
Molecular Weight	362.42 g/mol
Synonyms	1-Boc-4-[(2,3-dihydro-1,4-benzodioxin-2-carbonyl)amino]piperidine; 1-(tert-Butoxycarbonyl)-4-[(2,3-dihydro-1,4-benzodioxine-2-carbonyl)amino]piperidine; 4-[(1,4-Benzodioxan-2-carbonyl)amino]-1-(tert-butoxycarbonyl)piperidine; tert-Butyl 4-[(2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl)amino]piperidine-1-carboxylate; 4-[(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; BOC-Piperidine-4-carboxamide derivative; CAS 1241231-81-1
EINECS	Contact for details

Quality Control

Our 4-[(2,3-Dihydro-Benzo[1,4]Dioxine-2-Carbonyl)-Amino]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications, and specifications can be aligned with client requirements for advanced R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.