Description

tert-Butyl 3-(Difluoromethyl)Piperazine-1-Carboxylate is a high-value, Boc-protected piperazine derivative featuring a difluoromethyl substituent. This compound serves as a critical advanced pharmaceutical intermediate (API) for the synthesis of novel active ingredients. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and enzyme inhibitors due to its reactive piperazine nitrogen.
• Material Science: Potential precursor for specialty polymers and ligands in catalysis, leveraging its unique fluorine chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	tert-Butyl 3-(Difluoromethyl)Piperazine-1-Carboxylate
CAS No.	1240621-52-6
Molecular Formula	C10H18F2N2O2
Molecular Weight	236.26 g/mol
Synonyms	1-Boc-3-(difluoromethyl)piperazine; tert-Butyl 3-(difluoromethyl)-1-piperazinecarboxylate; 3-(Difluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-Piperazinecarboxylic acid, 3-(difluoromethyl)-, 1,1-dimethylethyl ester; Boc-3-(difluoromethyl)piperazine; N-Boc-3-(difluoromethyl)piperazine; 1240621-52-6
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-(Difluoromethyl)Piperazine-1-Carboxylate adheres to stringent quality management systems. Every batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, supporting cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.