Description

3-Fluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester (CAS NO 1240595-05-4) is a high-value, protected piperazine derivative serving as a critical building block in modern synthetic chemistry. Its core value lies in the strategic combination of a fluoromethyl group and a Boc-protected amine, enabling precise molecular construction for advanced applications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the fluoromethyl group enhances bioavailability and metabolic stability.
• Peptide Mimetics & PROTACs: Serves as a versatile scaffold for constructing peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine functionality.
• Ligand & Catalyst Development: Employed in creating specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Building Block: The fluoromethyl moiety makes it a valuable precursor for introducing fluorine atoms into complex molecules to alter their physicochemical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	3-Fluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240595-05-4
Molecular Formula	C11H21FN2O2
Molecular Weight	232.30 g/mol
Synonyms	1-Boc-3-(fluoromethyl)piperazine; tert-Butyl 3-(fluoromethyl)piperazine-1-carboxylate; 3-(Fluoromethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-3-fluoromethylpiperazine; 3-Fluoromethyl-1-Boc-piperazine; N-Boc-3-fluoromethylpiperazine; 3-(Fluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(fluoromethyl)piperazine
EINECS	Contact for details

Quality Control

Our 3-Fluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.