Description

(S)-2-Cyclopropyl-Piperazine is a high-purity, single-enantiomer chiral building block of significant importance in modern pharmaceutical research and development. Its unique cyclopropyl-substituted piperazine scaffold makes it a valuable intermediate for constructing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas. This compound is primarily sought after by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical synthesis industries for creating targeted molecular libraries and scalable synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in CNS disorders, antivirals, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained three-dimensional structure.
• Asymmetric Synthesis: Serves as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• API Development: Incorporated into the core structure of advanced pharmaceutical ingredients requiring specific stereochemistry.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up campaigns under cGMP or non-GMP conditions.

Basic Information

Product Name	(S)-2-Cyclopropyl-Piperazine
CAS No.	1240589-72-3
Molecular Formula	C7H14N2
Molecular Weight	126.20 g/mol
Synonyms	(S)-2-Cyclopropylpiperazine; (S)-2-Cyclopropyl-1,4-diazacyclohexane; (S)-2-Cyclopropyldiazinane; (2S)-2-Cyclopropylpiperazine; (S)-(-)-2-Cyclopropylpiperazine; Piperazine, 2-cyclopropyl-, (2S)-; (S)-2-CPP; (S)-CPP
EINECS	Contact for details

Quality Control

Our (S)-2-Cyclopropyl-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, critical for pharmaceutical applications. All material is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material suitable for research and development under quality standards appropriate for your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.