Description

(R)-5-Isobutyl-Piperazin-2-One CAS NO 1240589-69-8 is a high-purity, chiral piperazinone derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents, particularly in the creation of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic compounds, particularly for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis: Utilized as a building block in stereoselective synthesis to introduce the (R)-configured isobutyl-piperazinone moiety into more complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical entities.
• Peptidomimetic Development: Serves as a constrained scaffold in the design of peptidomimetics, which mimic the structure and function of peptides.
• Chemical Biology Probes: Used in the synthesis of specialized probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(R)-5-Isobutyl-Piperazin-2-One
CAS No.	1240589-69-8
Molecular Formula	C8H16N2O
Molecular Weight	156.23 g/mol
Synonyms	(R)-5-(2-Methylpropyl)piperazin-2-one; (R)-5-Isobutyl-2-piperazinone; (R)-5-(Isobutyl)-2-piperazinone; (R)-5-(2-Methylpropyl)-2-piperazinone; (R)-5-Isobutylpiperazin-2-one; (R)-5-Isobutyl-2,3,4,5-tetrahydropyrazin-2-one; (R)-5-(2-Methylpropyl)-3,4-dihydropyrazin-2(1H)-one; (R)-5-Isobutyl-3,4-dihydro-2(1H)-pyrazinone
EINECS	Contact for details

Quality Control

Our (R)-5-Isobutyl-Piperazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.