Description

(R)-tert-Butyl 3-tert-Butylpiperazine-1-Carboxylate Hydrochloride is a high-purity, chiral piperazine derivative and a critical building block in modern pharmaceutical synthesis. Its value lies in providing a structurally defined, enantiomerically pure scaffold essential for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, especially those targeting protein-protein interactions.
• API Development: Used in the research and process chemistry stages for constructing complex molecular architectures in active pharmaceutical ingredients.
• Asymmetric Synthesis: Employed as a building block to introduce stereogenic centers in medicinal chemistry campaigns, leveraging its tert-butyl-protected piperazine core.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.
• Process Optimization: Acts as a reference standard and intermediate in scaling up and optimizing synthetic routes for cost-effective manufacturing.

Basic Information

Product Name	(R)-tert-Butyl 3-tert-Butylpiperazine-1-Carboxylate Hydrochloride
CAS No.	1240588-24-2
Molecular Formula	C13H27N2O2•HCl
Molecular Weight	278.83 g/mol (Free base: 243.36 g/mol)
Synonyms	1-Boc-3-tert-butyl-(R)-piperazine hydrochloride; (R)-1-(tert-Butoxycarbonyl)-3-tert-butylpiperazine hydrochloride; tert-Butyl (R)-3-(tert-butyl)piperazine-1-carboxylate hydrochloride; (R)-3-tert-Butyl-1-Boc-piperazine HCl; (R)-1-N-Boc-3-tert-butylpiperazine hydrochloride; (R)-3-tert-Butylpiperazine-1-carboxylic acid tert-butyl ester hydrochloride; BOC-(R)-3-tert-butylpiperazine HCl
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-tert-Butylpiperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.