Description

1-Piperazinecarboxylic Acid, 2-Cyclobutyl-, 1,1-Dimethylethyl Ester, (2S)- is a high-purity chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a structurally defined, stereochemically pure scaffold essential for constructing complex molecules with specific biological activity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and antiviral targets.
• API Synthesis: Used in the construction of the piperazine core during the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a versatile, substituted piperazine template for library synthesis.
• Process Chemistry & Scale-Up: Serves as a validated starting material or intermediate in the optimization and pilot-scale production of clinical trial materials.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block to induce stereoselectivity in complex chemical transformations.
• Contract Research & Manufacturing (CRMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development services.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 2-Cyclobutyl-, 1,1-Dimethylethyl Ester, (2S)-
CAS No.	1240588-10-6
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	(2S)-2-Cyclobutyl-1-(tert-butoxycarbonyl)piperazine; tert-Butyl (2S)-2-cyclobutylpiperazine-1-carboxylate; (S)-2-Cyclobutyl-1-Boc-piperazine; (S)-N-Boc-2-cyclobutylpiperazine; (S)-1-Boc-2-cyclobutylpiperazine; 2-Cyclobutyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester, (2S)-; Boc-(S)-2-cyclobutylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 2-Cyclobutyl-, 1,1-Dimethylethyl Ester, (2S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) documenting identity, purity, and chiral excess are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.