Description

tert-Butyl (S)-2-(Trifluoromethyl)Piperazine-1-Carboxylate is a high-value, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in the trifluoromethyl group, which is strategically positioned to significantly influence the metabolic stability, lipophilicity, and binding affinity of final target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs, antivirals, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Peptidomimetics & Bioisosteres: Incorporated into peptide analogs and bioisosteric replacements to improve drug-like properties such as metabolic stability and membrane permeability.
• Material Science Research: Explored as a monomer or functional additive in specialty polymers and advanced materials for its unique fluorine-based properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	tert-Butyl (S)-2-(Trifluoromethyl)Piperazine-1-Carboxylate
CAS No.	1240588-06-0
Molecular Formula	C10H17F3N2O2
Molecular Weight	254.25 g/mol
Synonyms	1-Boc-(S)-2-(Trifluoromethyl)piperazine; (S)-1-(tert-Butoxycarbonyl)-2-(trifluoromethyl)piperazine; (S)-N-Boc-2-(Trifluoromethyl)piperazine; tert-Butyl (S)-2-(trifluoromethyl)-1-piperazinecarboxylate; (S)-2-(Trifluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-(S)-2-trifluoromethylpiperazine; (S)-1-Boc-2-Trifluoromethylpiperazine; Boc-(S)-2-CF3-piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-2-(Trifluoromethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.