Description

tert-Butyl (R)-2-(Trifluoromethyl)Piperazine-1-Carboxylate is a high-value, chiral piperazine derivative that serves as a critical building block in modern organic synthesis. Its primary value lies in its role as a key intermediate for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require enantiomerically pure intermediates to ensure the efficacy and safety of final products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the specific stereochemistry influences biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis to create other enantiomerically pure compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	tert-Butyl (R)-2-(Trifluoromethyl)Piperazine-1-Carboxylate
CAS No.	1240588-01-5
Molecular Formula	C10H17F3N2O2
Molecular Weight	254.25 g/mol
Synonyms	1-Boc-(R)-2-(Trifluoromethyl)piperazine; (R)-1-Boc-2-(Trifluoromethyl)piperazine; (R)-1-(tert-Butoxycarbonyl)-2-(trifluoromethyl)piperazine; tert-Butyl (R)-(-)-2-(trifluoromethyl)-1-piperazinecarboxylate; (R)-2-(Trifluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-(R)-2-trifluoromethylpiperazine; (R)-N-Boc-2-Trifluoromethylpiperazine; Boc-(R)-2-CF3-piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-2-(Trifluoromethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.