Description

(3S)-3-(Trifluoromethyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-value, chiral piperazine derivative featuring a strategically positioned trifluoromethyl group. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. The Boc-protected amine functionality and stereogenic center make it essential for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug leads.
• Agrochemical Synthesis: Intermediate for creating novel pesticides and herbicides that leverage the stability and lipophilicity of the trifluoromethyl group.
• Peptidomimetics Development: Serves as a constrained, non-natural amino acid analog in the design of peptide-based therapeutics.
• Ligand and Catalyst Preparation: Used to synthesize chiral ligands for asymmetric catalysis and organometallic complexes.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(3S)-3-(Trifluoromethyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1240587-95-4
Molecular Formula	C10H17F3N2O2
Molecular Weight	254.25 g/mol
Synonyms	tert-Butyl (3S)-3-(trifluoromethyl)piperazine-1-carboxylate; (S)-tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate; (S)-1-Boc-3-(trifluoromethyl)piperazine; (3S)-1-Boc-3-(trifluoromethyl)piperazine; (S)-3-Trifluoromethyl-1-Boc-piperazine; (S)-N-Boc-3-(trifluoromethyl)piperazine; 1,1-Dimethylethyl (3S)-3-(trifluoromethyl)-1-piperazinecarboxylate
EINECS	Contact for details

Quality Control

Our (3S)-3-(Trifluoromethyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality systems. We provide material with typical purity grades suitable for research and commercial development, supported by comprehensive analytical data. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are available for every batch. Our quality commitment ensures consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.