Description

3-Trifluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical building block for introducing the trifluoromethyl-piperazine moiety, a privileged scaffold known to enhance the metabolic stability and binding affinity of target molecules. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and CNS-targeting therapeutics.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of bioactive molecules, particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides and fungicides, leveraging the trifluoromethyl group for improved lipophilicity and biological activity.
• Chemical Biology: Serves as a versatile scaffold for constructing chemical probes and libraries used in high-throughput screening and target identification.
• Peptidomimetics: Employed in the design and synthesis of peptide analogs where the piperazine ring mimics natural amino acid side chains.
• Material Science: Potential monomer or precursor for specialty polymers and advanced materials with unique fluorinated properties.

Basic Information

Product Name	3-Trifluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240587-88-5
Molecular Formula	C10H17F3N2O2
Molecular Weight	254.25 g/mol
Synonyms	tert-Butyl 3-(trifluoromethyl)piperazine-1-carboxylate; 1-Boc-3-(trifluoromethyl)piperazine; 3-Trifluoromethyl-1-Boc-piperazine; 1-N-Boc-3-trifluoromethylpiperazine; 3-(Trifluoromethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-3-(trifluoromethyl)piperazine; 3-Trifluoromethylpiperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(trifluoromethyl)piperazine
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.