Description

(R)-3-Cyclopropyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, chiral piperazine derivative that serves as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined, protected piperazine core, enabling the efficient development of targeted bioactive molecules. This advanced intermediate is essential for research and production chemists in the pharmaceutical and biotechnology industries, particularly for creating novel drug candidates in therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) with complex piperazine-based architectures.
• Drug Discovery & Medicinal Chemistry: Used in research libraries and lead optimization programs to introduce the (R)-3-cyclopropyl-piperazine moiety into novel chemical entities.
• CNS-Targeting Therapeutics: Serves as a precursor for compounds targeting neurological receptors and enzymes, potentially for antidepressants, antipsychotics, or cognitive enhancers.
• Kinase Inhibitor Development: Incorporated into the structure of small-molecule kinase inhibitors for oncology and inflammatory disease applications.
• Asymmetric Synthesis: Utilized in stereoselective synthesis to construct molecules with high enantiomeric purity, leveraging its pre-defined (R) configuration.
• Contract Manufacturing & Development (CMO/CDMO): Supplied to outsourcing partners for cGMP and non-GMP scale-up projects requiring reliable, high-quality advanced intermediates.

Basic Information

Product Name	(R)-3-Cyclopropyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240587-11-4
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl (R)-3-cyclopropylpiperazine-1-carboxylate; (R)-1-Boc-3-cyclopropylpiperazine; (R)-3-Cyclopropyl-1-(tert-butoxycarbonyl)piperazine; (R)-N-Boc-3-cyclopropylpiperazine; (R)-1-N-Boc-3-cyclopropylpiperazine; (3R)-3-Cyclopropyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperazine; (R)-3-Cyclopropylpiperazine-1-carboxylic acid tert-butyl ester; (R)-1-Boc-3-cyclopropyl-piperazine
EINECS	Contact for details

Quality Control

Our (R)-3-Cyclopropyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data, including chiral purity verification, to support your regulatory and development needs. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.