Description

(2R,5R)-2,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for asymmetric synthesis and process optimization.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) agents and receptor modulators.
• Asymmetric Catalyst Ligand Precursor: Used to develop and manufacture chiral ligands for asymmetric hydrogenation and other catalytic processes.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and synthesizing peptide mimics with enhanced metabolic stability.
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring high stereochemical fidelity.
• Academic & Industrial R&D: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	(2R,5R)-2,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240586-48-4
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-(2R,5R)-2,5-dimethylpiperazine; tert-Butyl (2R,5R)-2,5-dimethylpiperazine-1-carboxylate; (2R,5R)-1-N-Boc-2,5-dimethylpiperazine; (2R,5R)-2,5-Dimethyl-1-(tert-butoxycarbonyl)piperazine; Boc-(2R,5R)-DMP; (2R,5R)-1-Boc-2,5-dimethylpiperazine; (R,R)-1-Boc-2,5-dimethylpiperazine
EINECS	Contact for details

Quality Control

Our (2R,5R)-2,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.