Description

(S)-3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester CAS NO 1240585-46-9 is a high-value, chiral piperazine derivative featuring a trifluoroethyl side chain and a Boc-protected amine. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of targeted therapeutics. It is primarily utilized by pharmaceutical R&D and manufacturing organizations engaged in developing novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) agents and oncology.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Used in research for structure-activity relationship (SAR) studies and lead optimization.
• Protease Inhibitor Development: The piperazine scaffold is common in the development of protease inhibitors for various therapeutic areas.
• Kinase Inhibitor Synthesis: Employed in the construction of kinase inhibitor candidates, a major class in oncology drug development.
• CNS-Active Compound Manufacturing: The trifluoroethyl group and piperazine core are pharmacophores found in compounds targeting neurological pathways.
• Peptidomimetic Chemistry: Serves as a constrained dipeptide mimic or a conformational restriction element in peptide-based drug design.
• Asymmetric Synthesis: The chiral (S)-configuration makes it a valuable starting material for enantioselective synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	(S)-3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240585-46-9
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	(S)-1-Boc-3-(2,2,2-trifluoroethyl)piperazine; tert-Butyl (S)-3-(2,2,2-trifluoroethyl)piperazine-1-carboxylate; (S)-3-(Trifluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; (S)-1-N-Boc-3-(2,2,2-trifluoroethyl)piperazine; (S)-N-Boc-3-(2,2,2-trifluoroethyl)piperazine; Boc-(S)-3-(2,2,2-trifluoroethyl)piperazine; (S)-3-(2,2,2-Trifluoroethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical-grade intermediate adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and consistency, supporting our clients' regulatory filings. Certificates of Analysis (COA) detailing comprehensive analytical results (including chiral purity, assay, and impurity profiles) are provided with each shipment. Our quality system is designed to meet the demands of cGMP manufacturing and global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.