Description

(2R,5R)-2,5-Diisobutyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, stereochemically defined piperazine derivative used as a critical chiral building block in advanced organic synthesis. This compound matters because it provides a rigid, functionalized scaffold essential for constructing complex molecules with high enantiomeric purity. It is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), particularly in creating novel therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Catalyst Ligand Precursor: Used to develop sophisticated ligands for transition metal catalysis, enabling highly enantioselective transformations.
• Peptidomimetics & Constrained Peptide Design: Serves as a conformationally restricted diamine component to mimic peptide secondary structures and enhance metabolic stability.
• Chemical Biology Probe Development: Incorporated into molecular probes to study enzyme function and receptor-ligand interactions due to its defined stereochemistry.
• High-Value Agrochemical Synthesis: Employed in the research phase for creating enantiomerically pure agrochemicals with specific modes of action.

Basic Information

Product Name	(2R,5R)-2,5-Diisobutyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240585-34-5
Molecular Formula	C18H36N2O2
Molecular Weight	312.50 g/mol
Synonyms	(2R,5R)-2,5-Diisobutyl-1-Boc-piperazine; tert-Butyl (2R,5R)-2,5-diisobutylpiperazine-1-carboxylate; (2R,5R)-1-Boc-2,5-diisobutylpiperazine; (2R,5R)-2,5-Diisobutyl-1-(tert-butoxycarbonyl)piperazine; Boc-(2R,5R)-2,5-Diisobutylpiperazine; (2R,5R)-2,5-Bis(2-methylpropyl)-1-(tert-butoxycarbonyl)piperazine; 1-N-Boc-(2R,5R)-2,5-diisobutylpiperazine
EINECS	Contact for details

Quality Control

Our (2R,5R)-2,5-Diisobutyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.