Description

tert-Butyl (S)-2-(2,2,2-Trifluoroethyl)Piperazine-1-Carboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a protected, enantiomerically pure scaffold essential for constructing complex molecules with defined stereochemistry. Pharmaceutical researchers and fine chemical manufacturers need it for the development of active pharmaceutical ingredients (APIs), particularly in neurological and oncological therapeutic areas, where the trifluoroethyl group can modulate pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced, enantiomerically pure pesticides and herbicides where specific stereochemistry is required for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: Incorporated into peptide backbones to enhance metabolic stability and binding affinity in medicinal chemistry programs.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high stereochemical fidelity and purity.

Basic Information

Product Name	tert-Butyl (S)-2-(2,2,2-Trifluoroethyl)Piperazine-1-Carboxylate
CAS No.	1240582-25-5
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	1-Boc-(S)-2-(2,2,2-Trifluoroethyl)piperazine; (S)-1-(tert-Butoxycarbonyl)-2-(2,2,2-trifluoroethyl)piperazine; tert-Butyl (S)-2-(2,2,2-trifluoroethyl)-1-piperazinecarboxylate; (S)-2-(2,2,2-Trifluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-(S)-2-(2,2,2-trifluoroethyl)piperazine; Boc-(S)-2-(TFE)piperazine; (S)-1-Boc-2-(2,2,2-trifluoroethyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-2-(2,2,2-Trifluoroethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.