Description

(R)-3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, chiral piperazine derivative featuring a trifluoroethyl side chain and a Boc-protected amine. This compound is a critical pharmaceutical intermediate valued for its role in constructing complex molecules with defined stereochemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoroethyl group can enhance biological activity and metabolic stability.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of diverse piperazine-based compound libraries for screening.
• Process Chemistry: Employed in route scouting and scale-up processes for the commercial manufacturing of fine chemicals.
• Academic Research: Utilized in universities and R&D labs for methodological studies in asymmetric synthesis and organofluorine chemistry.
• Ligand & Catalyst Development: The chiral piperazine core can be incorporated into ligands for asymmetric catalysis.

Basic Information

Product Name	(R)-3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1240582-23-3
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	(R)-1-Boc-3-(2,2,2-trifluoroethyl)piperazine; (R)-tert-Butyl 3-(2,2,2-trifluoroethyl)piperazine-1-carboxylate; (R)-3-(Trifluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; (R)-N-Boc-3-(2,2,2-trifluoroethyl)piperazine; (R)-1-(tert-Butoxycarbonyl)-3-(2,2,2-trifluoroethyl)piperazine; (R)-Boc-3-(2,2,2-trifluoroethyl)piperazine; (R)-3-(2,2,2-Trifluoroethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (R)-3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.