Description

tert-Butyl 6-Chloro-4-Formylpyridin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its reactive aldehyde and protected carbamate functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other small molecule drug candidates.
• Organic Synthesis: Serves as a versatile precursor for further functionalization via reactions at the formyl group or after deprotection of the carbamate.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Custom Synthesis: Employed in the contract manufacturing of complex, proprietary molecules for clinical trials.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	tert-Butyl 6-Chloro-4-Formylpyridin-3-Ylcarbamate
CAS No.	1238324-67-8
Molecular Formula	C11H13ClN2O3
Molecular Weight	256.69 g/mol
Synonyms	3-[[(1,1-Dimethylethoxy)carbonyl]amino]-6-chloro-4-pyridinecarboxaldehyde; tert-Butyl (6-chloro-4-formylpyridin-3-yl)carbamate; 6-Chloro-4-formylpyridin-3-yl-carbamic acid tert-butyl ester; 3-(tert-Butoxycarbonylamino)-6-chloro-isonicotinaldehyde; BOC-6-Chloro-4-formyl-3-aminopyridine; 6-Chloro-4-formyl-3-((tert-butoxycarbonyl)amino)pyridine; 3-Amino-6-chloro-4-pyridinecarboxaldehyde tert-butyl carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Chloro-4-Formylpyridin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.