Description

Mpeg16-Br CAS NO 1238189-11-1 is a high-purity, monodisperse polyethylene glycol (PEG) derivative functionalized with a bromine (Br) group, specifically featuring a 16-unit PEG spacer. This compound is a critical intermediate for advanced bioconjugation and polymer chemistry, enabling precise, site-specific modifications of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality functional linkers for drug delivery systems, diagnostic assays, and hydrogel synthesis.

Application

• Bioconjugation Linker: Used as a heterobifunctional crosslinker for attaching drugs, peptides, or fluorescent dyes to antibodies, proteins, or nanoparticles in ADC (Antibody-Drug Conjugate) development and diagnostic probe synthesis.
• Polymer Initiator/Macroinitiator: Serves as an initiator for Atom Transfer Radical Polymerization (ATRP) to create well-defined, PEG-based block copolymers with controlled molecular weights and architectures.
• Surface Functionalization: Employed to introduce reactive bromine groups onto material surfaces (e.g., gold, silica) or existing polymers for subsequent "click" chemistry or further chain extension.
• Hydrogel Formation: Acts as a crosslinking agent or a functional precursor in the synthesis of PEG-based hydrogels for tissue engineering and controlled release applications.
• Lipid-PEG Conjugate Synthesis: A key building block for creating lipid-PEG conjugates (e.g., DSPE-PEG, cholesterol-PEG) used in liposomal and lipid nanoparticle (LNP) formulations for mRNA and siRNA delivery.
• Prodrug Synthesis: Facilitates the design of prodrugs by providing a cleavable PEG spacer between an active pharmaceutical ingredient and a targeting moiety.

Basic Information

Product Name	Mpeg16-Br
CAS No.	1238189-11-1
Molecular Formula	C34H69BrO16 (Typical for mPEG16-Br)
Molecular Weight	~813.81 g/mol (Theoretical)
Synonyms	mPEG16-Br; Bromo-PEG16-OMe; Methoxy-PEG16-bromide; α-Methoxy-ω-bromo hexadeca(ethylene glycol); 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl bromide; Poly(ethylene glycol) methyl ether brominated; Br-PEG16-OCH3
EINECS	Contact for details

Quality Control

Our Mpeg16-Br is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H and ¹³C) for structural confirmation, HPLC for purity and monodispersity assessment, and mass spectrometry for molecular weight verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight	800 - 830 g/mol
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.