Description

tert-Butyl 4-Fluoro-3-Iodopyridin-2-Ylcarbamate is a high-purity, multi-functional chemical building block designed for advanced synthetic applications. This compound is valued for its unique halogenated pyridine core, which provides versatile reactivity for constructing complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Serves as a critical building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Used in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form new carbon-carbon bonds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study biological processes and enzyme functions.

Basic Information

Product Name	tert-Butyl 4-Fluoro-3-Iodopyridin-2-Ylcarbamate
CAS No.	1237535-77-1
Molecular Formula	C10H12FIN2O2
Molecular Weight	338.12 g/mol
Synonyms	2-Pyridinecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-iodo-; tert-Butyl N-(4-fluoro-3-iodopyridin-2-yl)carbamate; Boc-4-Fluoro-3-Iodo-2-aminopyridine; N-Boc-4-Fluoro-3-iodopyridin-2-amine; 4-Fluoro-3-iodo-2-((tert-butoxycarbonyl)amino)pyridine; 2-((tert-Butoxycarbonyl)amino)-4-fluoro-3-iodopyridine; 1237535-77-1; TB-4F-3I-Py-2-Carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Fluoro-3-Iodopyridin-2-Ylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.