Description

2-(Piperidin-4-Yloxy)-5-(Trifluoromethyl)Pyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with significant synthetic utility. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and other therapeutic areas. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process scale-up.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, especially those containing piperidine and trifluoromethylpyridine pharmacophores.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a standardized building block for developing robust, scalable synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential application in the development of novel crop protection agents and pesticides due to its heterocyclic structure.
• Chemical Biology Probes: Can be utilized in the design of molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	2-(Piperidin-4-Yloxy)-5-(Trifluoromethyl)Pyridine Dihydrochloride
CAS No.	1236458-57-3
Molecular Formula	C11H14F3N2O • 2HCl
Molecular Weight	331.16 g/mol (Free base)
Synonyms	5-(Trifluoromethyl)-2-(4-piperidinyloxy)pyridine dihydrochloride; 2-((Piperidin-4-yl)oxy)-5-(trifluoromethyl)pyridine hydrochloride (1:2); 4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)piperidine dihydrochloride; 2-(4-Piperidyloxy)-5-trifluoromethylpyridine dihydrochloride; 2-(Piperidin-4-yloxy)-5-(trifluoromethyl)pyridine 2HCl; CAS 1236458-57-3
EINECS	Contact for details

Quality Control

Our production of 2-(Piperidin-4-Yloxy)-5-(Trifluoromethyl)Pyridine Dihydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.