Description

(8Ar)-Tetrahydro-3-Oxo-3H-Oxazolo[3,4-A]Pyrazine-7(1H)-Carboxylic Acid 1,1-Dimethylethyl Ester is a sophisticated heterocyclic building block and protected amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate, enabling the precise construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and metabolic diseases.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs and protease inhibitors due to its fused oxazolopyrazine scaffold, which can mimic peptide turn structures.
• Medicinal Chemistry Research: Provides a versatile platform for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective reactions to introduce chiral centers with high enantiomeric purity.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Process Chemistry Development: Acts as a key intermediate for scaling up the production of target molecules from laboratory to pilot plant scale.

Basic Information

Product Name	(8Ar)-Tetrahydro-3-Oxo-3H-Oxazolo[3,4-A]Pyrazine-7(1H)-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1235469-36-9
Molecular Formula	C12H18N2O4
Molecular Weight	254.28 g/mol
Synonyms	tert-Butyl (8aR)-3-oxo-1,2,3,5,8,8a-hexahydrooxazolo[3,4-a]pyrazine-7-carboxylate; (8aR)-Hexahydro-3-oxo-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxylic acid 1,1-dimethylethyl ester; Boc-Protected Oxazolopyrazine Derivative; (R)-tert-Butyl 3-oxo-2,3,6,7,8,8a-hexahydro-1H-oxazolo[3,4-a]pyrazine-7-carboxylate; Chiral Oxazolopyrazine Ester; CAS 1235469-36-9
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity (HPLC assay), chiral purity, and residual solvent levels are available upon request. Our quality system supports development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.