Description

tert-Butyl 8-Bromo-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound matters as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to facilitate efficient and scalable synthetic routes for complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indole and tetrahydro-β-carboline-based drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• API Development: Serves as a crucial building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• CNS Drug Discovery: Particularly relevant for research targeting neurological disorders due to its core tetrahydro-2H-pyrido[4,3-b]indole scaffold.
• Oncology Research: Utilized in the development of novel small-molecule inhibitors and targeted therapies.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocycle synthesis.

Basic Information

Item	Detail
Product Name	tert-Butyl 8-Bromo-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate
CAS No.	1234685-60-9
Molecular Formula	C16H19BrN2O2
Molecular Weight	351.24 g/mol
Synonyms	8-Bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate; 8-Bromo-2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 8-Bromo-2-Boc-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 8-Bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; 8-Bromo-2-Boc-tetrahydro-β-carboline derivative; 8-Br-THPI-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Bromo-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in GMP-compliant supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere such as nitrogen or argon when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.