Description

1H-Pyrazolo[3,4-B]Pyridine-5-Carbonitrile is a high-value nitrogen-containing heterocyclic building block, specifically a fused pyrazolopyridine derivative. This compound is a critical intermediate in modern pharmaceutical and agrochemical research, prized for its unique molecular scaffold that enables the synthesis of novel active ingredients. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for the discovery and development of new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small molecule drug candidates targeting various diseases.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a precursor for creating advanced organic electronic materials and functional dyes.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Academic & Contract Research: Essential for synthetic methodology development and exploration of new chemical space in university and CRO laboratories.

Basic Information

Product Name	1H-Pyrazolo[3,4-B]Pyridine-5-Carbonitrile
CAS No.	1234616-67-1
Molecular Formula	C7H4N4
Molecular Weight	144.14 g/mol
Synonyms	1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile; 5-Cyano-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile; Pyrazolo[3,4-b]pyridine-5-carbonitrile; 5-Pyrazolo[3,4-b]pyridinecarbonitrile; 1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile (9CI)
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-5-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects with material suitable for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.