Description

Methyl 4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylate is a high-purity fluorinated heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its core value lies in its versatile pyrrolopyridine scaffold, which serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents. This compound is primarily needed by R&D chemists and process development scientists in the life sciences sector seeking to incorporate advanced fluorine-containing motifs into their molecular designs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyrrolopyridine core.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the construction of targeted molecular libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate in the optimization and commercial-scale production of active ingredients.
• Fluorine Chemistry: A valuable substrate for further functionalization, exploring the unique effects of fluorine substitution on pharmacokinetic properties.

Basic Information

Product Name	Methyl 4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylate
CAS No.	1234615-74-7
Molecular Formula	C9H7FN2O2
Molecular Weight	194.16 g/mol
Synonyms	4-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; Methyl 4-fluoro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 4-fluoro-, methyl ester; 4-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid, methyl ester; 1234615-74-7; 4-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-methyl carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.