Description

2-Oxopyrrolidine-3-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound is particularly valued for its role as a key building block in the development of novel pharmaceutical actives and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of N-methyl-D-aspartate (NMDA) receptor antagonists, nootropic agents, and other central nervous system (CNS) active compounds.
• Peptidomimetic Chemistry: Used to introduce the 2-oxopyrrolidine-3-carbonyl moiety, a common scaffold in protease inhibitors and bioactive peptide analogs.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides and plant growth regulators with specific activity profiles.
• Material Science Research: Employed in the development of specialty polymers and functional materials requiring specific lactam-based linkages.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.
• Academic & R&D: Utilized in medicinal chemistry laboratories for hit-to-lead optimization and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Oxopyrrolidine-3-Carbonyl Chloride
CAS No.	1234440-94-8
Molecular Formula	C6H6ClNO2
Molecular Weight	159.57 g/mol
Synonyms	3-(Chlorocarbonyl)-2-pyrrolidinone; 2-Oxo-3-pyrrolidinecarbonyl chloride; 3-Carbamoyl-2-pyrrolidinone chloride; Pyrrolidin-2-one-3-carbonyl chloride; 3-Pyrrolidinecarboxylic acid, 2-oxo-, chloride; 1,5-Dihydro-2H-pyrrol-2-one-3-carbonyl chloride; (3-Oxo-1-pyrrolidinyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Oxopyrrolidine-3-Carbonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and IR is supplied with each shipment to guarantee supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.