Description

tert-Butyl 4-(2-Aminophenylsulfonamido)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a protected amine and a sulfonamide-linked aniline moiety. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. Pharmaceutical research and development organizations need this intermediate for creating novel drug candidates targeting central nervous system disorders, oncology, and other specialized therapeutic fields.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates, particularly in medicinal chemistry research.
• Protease Inhibitor Synthesis: Used in the development of protease inhibitors, leveraging its sulfonamide and protected amine functionalities.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the creation of kinase inhibitors for oncology and inflammatory disease research.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for target identification and validation in biological systems.
• Peptidomimetic Research: The piperidine and sulfonamide structure makes it valuable for constructing peptidomimetics and conformationally constrained analogs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 4-(2-Aminophenylsulfonamido)Piperidine-1-Carboxylate
CAS No.	1233958-26-3
Molecular Formula	C16H25N3O4S
Molecular Weight	355.45 g/mol
Synonyms	1-Boc-4-[(2-aminophenyl)sulfonylamino]piperidine; 4-[(2-Aminobenzene)sulfonylamino]-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 4-{[(2-aminophenyl)sulfonyl]amino}piperidine-1-carboxylate; N-(1-Boc-4-piperidinyl)-2-aminobenzenesulfonamide; 2-Amino-N-(1-Boc-4-piperidinyl)benzenesulfonamide; 1-Boc-4-(2-aminobenzenesulfonamido)piperidine; 4-(2-Aminophenylsulfonamido)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Aminophenylsulfonamido)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.