Description

tert-Butyl 4-(4-Methoxyphenylsulfonamido)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and functionalized with a 4-methoxyphenylsulfonamide moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of complex small-molecule APIs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those requiring a functionalized piperidine scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Protease Inhibitor Synthesis: The sulfonamide and protected amine functionalities make it relevant for constructing molecules that interact with enzyme active sites.
• Kinase Inhibitor Development: Serves as a core structural element in the research of kinase-targeted therapies for oncology and inflammatory diseases.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.
• Academic Research: Employed in university and institutional labs for chemical biology studies and novel synthetic methodology development.

Basic Information

Product Name	tert-Butyl 4-(4-Methoxyphenylsulfonamido)Piperidine-1-Carboxylate
CAS No.	1233958-22-9
Molecular Formula	C17H26N2O5S
Molecular Weight	370.46 g/mol
Synonyms	1-Boc-4-[(4-methoxyphenyl)sulfonylamino]piperidine; 4-[(4-Methoxyphenyl)sulfonylamino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-[(4-methoxyphenyl)sulfonamido]piperidine-1-carboxylate; N-(1-Boc-piperidin-4-yl)-4-methoxybenzenesulfonamide; 4-Methoxy-N-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzenesulfonamide; Boc-4-(4-Methoxybenzenesulfonamido)piperidine; 1-Boc-4-(Tosyl(4-OMe)-amino)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Methoxyphenylsulfonamido)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. The product is suitable for use under non-GMP and, upon request, cGMP conditions for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.