Description

(1R*,4R*)-4-(3-Aminopyridin-2-Ylamino)Cyclohexanol CAS NO 1233955-66-2 is a high-purity, stereochemically defined chiral intermediate of significant importance in modern pharmaceutical synthesis. Its core value lies in its unique molecular scaffold, which serves as a critical building block for constructing complex, biologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and CNS disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in the construction of complex molecules requiring specific stereochemistry due to its defined (1R*,4R*) configuration.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial APIs.

Basic Information

Product Name	(1R*,4R*)-4-(3-Aminopyridin-2-Ylamino)Cyclohexanol
CAS No.	1233955-66-2
Molecular Formula	C11H16N4O
Molecular Weight	220.27 g/mol
Synonyms	(1R*,4R*)-4-[(3-Aminopyridin-2-yl)amino]cyclohexanol; 4-[(3-Amino-2-pyridinyl)amino]cyclohexanol, (1R,4R)-rel-; rel-(1R,4R)-4-[(3-Aminopyridin-2-yl)amino]cyclohexanol; (1R,4R)-4-((3-Aminopyridin-2-yl)amino)cyclohexanol (racemic relative stereochemistry); 2-(((1R,4R)-4-Hydroxycyclohexyl)amino)pyridin-3-amine; CAS 1233955-66-2; Bicyclic aminopyridine derivative intermediate
EINECS	Contact for details

Quality Control

Our (1R*,4R*)-4-(3-Aminopyridin-2-Ylamino)Cyclohexanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), chiral purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (1R*,4R*) isomer
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.