Description

tert-Butyl 4-(4-Nitrophenylsulfonamido)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and functionalized with a 4-nitrophenylsulfonamide moiety. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily needed by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of new therapeutic agents, especially those targeting neurological disorders and other conditions where piperidine-based scaffolds are prevalent.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic compounds.
• Protease Inhibitor Development: The sulfonamide functional group makes it a valuable precursor in the design of enzyme inhibitors.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes used to study biological pathways.
• Custom Synthesis: Employed by fine chemical manufacturers for the contract synthesis of specialized, non-commercial compounds for client R&D.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl 4-(4-Nitrophenylsulfonamido)Piperidine-1-Carboxylate
CAS No.	1233952-63-0
Molecular Formula	C16H23N3O6S
Molecular Weight	385.44 g/mol
Synonyms	1-Boc-4-[(4-nitrophenyl)sulfonylamino]piperidine; 4-[(4-Nitrobenzenesulfonyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-((4-nitrophenyl)sulfonamido)piperidine-1-carboxylate; 1,1-Dimethylethyl 4-[[(4-nitrophenyl)sulfonyl]amino]-1-piperidinecarboxylate; 4-(4-Nitrobenzenesulfonamido)piperidine-1-carboxylic acid tert-butyl ester; N-(1-Boc-4-piperidyl)-4-nitrobenzenesulfonamide; Boc-4-(4-NO2-Phenylsulfonamido)piperidine
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 4-(4-Nitrophenylsulfonamido)Piperidine-1-Carboxylate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D. Our quality commitment includes comprehensive identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.