Description

1-(2-Fluoro-6-Nitrophenyl)Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct fluorinated aromatic structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and psychiatric disorder therapeutics. Pharmaceutical R&D teams and fine chemical manufacturers need this building block for its ability to introduce both a fluorine atom and a piperazine moiety, which are key pharmacophores for optimizing drug potency, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for CNS-targeted therapies.
• Biochemical Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Fluorinated Compound Library Synthesis: Essential for creating specialized libraries of fluorinated compounds for high-throughput screening in drug discovery.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and process development for clients.
• Academic Research: Utilized in university and institutional labs for exploratory research in organic and medicinal chemistry.

Basic Information

Product Name	1-(2-Fluoro-6-Nitrophenyl)Piperazine Hydrochloride
CAS No.	1233952-17-4
Molecular Formula	C10H11FN3O2·HCl
Molecular Weight	261.67 g/mol (Free base: 225.21 g/mol)
Synonyms	1-(2-Fluoro-6-nitrophenyl)piperazine hydrochloride; 2-Fluoro-6-nitro-1-piperazinobenzene hydrochloride; 1-(2-Fluoro-6-nitrophenyl)piperazine HCl; 1-Piperazine, 1-(2-fluoro-6-nitrophenyl)-, hydrochloride; 2-Fluoro-6-nitrophenylpiperazine hydrochloride; 1-(2-Fluoro-6-nitro-phenyl)-piperazine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-6-Nitrophenyl)Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.