Description

1-(3-Fluoro-2-Nitrophenyl)Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core and fluoronitrophenyl substitution. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug discovery pipelines. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting serotonin and dopamine receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for the development of new APIs with potential antipsychotic, antidepressant, or anxiolytic properties.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Fine Chemical Synthesis: Used in the preparation of more complex, functionalized chemical entities for various specialty chemical applications.

Basic Information

Product Name	1-(3-Fluoro-2-Nitrophenyl)Piperazine Hydrochloride
CAS No.	1233952-08-3
Molecular Formula	C10H13FN3O2 • HCl
Molecular Weight	259.69 g/mol (Free base: 223.23 g/mol)
Synonyms	1-(3-Fluoro-2-nitrophenyl)piperazine hydrochloride; 1-(3-Fluoro-2-nitrophenyl)piperazine HCl; Piperazine, 1-(3-fluoro-2-nitrophenyl)-, hydrochloride; 3-Fluoro-2-nitrophenylpiperazine hydrochloride; 1-(3-Fluoro-2-nitro-phenyl)-piperazine hydrochloride; 1233952-08-3; CAS 1233952-08-3
EINECS	Contact for details

Quality Control

Our 1-(3-Fluoro-2-Nitrophenyl)Piperazine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material that aligns with ICH Q7 guidelines and current Good Manufacturing Practice (cGMP) principles upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.