Description

tert-Butyl 4-[(5-Nitropyridin-2-ylamino)methyl]piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core functionalized with a nitropyridine moiety. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly within therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a critical building block for constructing libraries of compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Synthesis: Used in the synthesis pathway for potential kinase inhibitors, given the prevalence of similar nitropyridine and piperidine motifs in this drug class.
• Chemical Biology Probes: Employed in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	tert-Butyl 4-[(5-Nitropyridin-2-ylamino)methyl]piperidine-1-carboxylate
CAS No.	1233952-06-1
Molecular Formula	C16H24N4O4
Molecular Weight	336.39 g/mol
Synonyms	1-Boc-4-[(5-nitropyridin-2-ylamino)methyl]piperidine; 1-(tert-Butoxycarbonyl)-4-[(5-nitropyridin-2-ylamino)methyl]piperidine; 4-[(5-Nitropyridin-2-ylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-({[(5-nitropyridin-2-yl)amino]methyl})piperidine-1-carboxylate; 2-({[1-(tert-Butoxycarbonyl)piperidin-4-yl]methyl}amino)-5-nitropyridine; 1233952-06-1; BOC-4-((5-Nitropyridin-2-ylamino)methyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(5-Nitropyridin-2-ylamino)methyl]piperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.