Description

(S)-tert-Butyl 1-(3-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate CAS NO 1233860-19-9 is a high-purity chiral intermediate featuring a protected amine and a pyrrolidine-pyridine scaffold. This compound is critical for pharmaceutical research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile functional groups.
• Process Chemistry Development: Serves as a chiral starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Proteolysis-Targeting Chimera (PROTAC) Development: A potential component in the linker or ligand moiety for designing bifunctional degraders.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and cellular pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	(S)-tert-Butyl 1-(3-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	1233860-19-9
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl N-[(3S)-1-(3-amino-2-pyridinyl)pyrrolidin-3-yl]carbamate; (S)-tert-Butyl (1-(3-aminopyridin-2-yl)pyrrolidin-3-yl)carbamate; (3S)-1-(3-Amino-2-pyridinyl)-3-pyrrolidinylcarbamic Acid 1,1-Dimethylethyl Ester; 1233860-19-9; (S)-Boc-3-amino-1-(3-amino-2-pyridyl)pyrrolidine; (S)-1-(3-Aminopyridin-2-yl)pyrrolidin-3-yl-carbamic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 1-(3-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards, and custom synthesis under cGMP guidelines is available for advanced clinical-stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.