Description

(R)-1-(5-Nitropyridin-2-Yl)Pyrrolidin-3-Amine Hydrochloride is a high-purity chiral amine building block and pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies developing active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and other targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in catalytic and stoichiometric asymmetric synthesis to introduce stereochemical complexity.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and target validation.
• Process Chemistry Development: Investigated for scalable synthetic routes in the pilot and commercial-scale manufacturing of chiral drugs.

Basic Information

Product Name	(R)-1-(5-Nitropyridin-2-Yl)Pyrrolidin-3-Amine Hydrochloride
CAS No.	1233860-13-3
Molecular Formula	C9H13ClN4O2
Molecular Weight	244.68 g/mol
Synonyms	(R)-3-Amino-1-(5-nitropyridin-2-yl)pyrrolidine hydrochloride; (R)-1-(5-Nitro-2-pyridinyl)-3-pyrrolidinamine hydrochloride; (R)-1-(5-Nitropyridin-2-yl)pyrrolidin-3-amine HCl; (R)-1-(5-Nitro-2-pyridyl)pyrrolidin-3-amine hydrochloride; (3R)-1-(5-Nitropyridin-2-yl)pyrrolidin-3-amine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(5-Nitropyridin-2-Yl)Pyrrolidin-3-Amine Hydrochloride is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to cGMP principles where applicable to support pharmaceutical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.