Description

(S)-tert-Butyl 1-(3-Nitropyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its core value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug candidates, especially for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel APIs requiring a specific (S)-configured pyrrolidine scaffold.
• Chemical Synthesis Research: Serves as a versatile intermediate in academic and industrial research for exploring new synthetic pathways and methodologies.
• Preclinical & Clinical Trial Material: Supplied under controlled conditions for the production of materials used in non-clinical and clinical studies.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Utilized in reactions where the introduction of a specific stereocenter is crucial for biological activity.

Basic Information

Product Name	(S)-tert-Butyl 1-(3-Nitropyridin-2-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	1233860-11-1
Molecular Formula	C14H20N4O4
Molecular Weight	308.33 g/mol
Synonyms	(S)-tert-Butyl (1-(3-nitropyridin-2-yl)pyrrolidin-3-yl)carbamate; (S)-1-(3-Nitro-2-pyridinyl)-3-[[(1,1-dimethylethoxy)carbonyl]amino]pyrrolidine; tert-Butyl N-[(3S)-1-(3-nitropyridin-2-yl)pyrrolidin-3-yl]carbamate; (S)-1-(3-Nitropyridin-2-yl)pyrrolidin-3-ylcarbamic acid tert-butyl ester; Boc-(S)-3-Amino-1-(3-nitro-2-pyridyl)pyrrolidine; (S)-3-((tert-Butoxycarbonyl)amino)-1-(3-nitropyridin-2-yl)pyrrolidine; (S)-Boc-3-Amino-1-(3-nitro-2-pyridinyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 1-(3-Nitropyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.