Description

(R)-tert-Butyl 1-(3-Nitropyridine-2-Yl)Pyrrolidine-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries who are engaged in the synthesis of complex, nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial-scale production of advanced pharmaceutical intermediates (APIs).
• Asymmetric Synthesis: Serves as a precursor for introducing the chiral pyrrolidine scaffold into complex molecular architectures, leveraging its stereogenic center.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the discovery of new chemical entities (NCEs) within academic and industrial R&D labs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific, high-value intermediates.

Basic Information

Product Name	(R)-tert-Butyl 1-(3-Nitropyridine-2-Yl)Pyrrolidine-3-Ylcarbamate
CAS No.	1233859-91-0
Molecular Formula	C14H20N4O4
Molecular Weight	308.33 g/mol
Synonyms	(R)-tert-Butyl 1-(3-nitropyridin-2-yl)pyrrolidine-3-ylcarbamate; tert-Butyl N-[(3R)-1-(3-nitropyridin-2-yl)pyrrolidin-3-yl]carbamate; (R)-1-(3-Nitro-2-pyridinyl)-3-[(tert-butoxycarbonyl)amino]pyrrolidine; Boc-(R)-3-Amino-1-(3-nitro-2-pyridyl)pyrrolidine; (R)-3-((tert-Butoxycarbonyl)amino)-1-(3-nitropyridin-2-yl)pyrrolidine; (R)-tert-Butyl (1-(3-nitropyridin-2-yl)pyrrolidin-3-yl)carbamate; CAS 1233859-91-0
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(3-Nitropyridine-2-Yl)Pyrrolidine-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC), to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.