Description

(R)-tert-Butyl 1-(3-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for constructing complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and other therapeutic areas. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug molecules, particularly for neurological and psychiatric disorders.
• API Development: Used in research and development for constructing the core scaffold of new Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Serves as a key starting material or intermediate in stereoselective chemical reactions to introduce specific chiral centers.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug efficacy and safety profiles.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.
• Pre-clinical & Clinical Development: Integral to the synthesis of compounds for pre-clinical testing and clinical trial material (CTM) manufacturing.

Basic Information

Product Name	(R)-tert-Butyl 1-(3-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	1233859-84-1
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	Carbamic acid, N-[(3R)-1-(3-amino-2-pyridinyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; (R)-tert-Butyl (1-(3-aminopyridin-2-yl)pyrrolidin-3-yl)carbamate; (R)-N-Boc-1-(3-aminopyridin-2-yl)pyrrolidin-3-amine; (R)-3-((tert-Butoxycarbonyl)amino)-1-(3-aminopyridin-2-yl)pyrrolidine; (R)-1-(3-Aminopyridin-2-yl)-N-Boc-pyrrolidin-3-amine; (R)-tert-Butyl 1-(3-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate; (3R)-1-(3-Amino-2-pyridinyl)-N-[(1,1-dimethylethoxy)carbonyl]-3-pyrrolidinamine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(3-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.