Description

(E)-Methyl 5-(6-Chloropyridin-3-Yl)-3-Oxopent-4-Enoate is a high-purity, advanced pharmaceutical intermediate characterized by its specific α,β-unsaturated ester and chloropyridine functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, offering a precise building block for constructing sophisticated molecular architectures. It is primarily utilized by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry research for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Serves as a crucial precursor in the development of next-generation insecticides and herbicides, leveraging the bioactivity of the chloropyridine moiety.
• Chemical Research & Development: Used as a versatile Michael acceptor or electrophile in organic synthesis for constructing complex heterocyclic compounds and natural product analogs.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target molecules requiring this specific stereochemistry and functional group array.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP or non-GMP conditions.

Basic Information

Product Name	(E)-Methyl 5-(6-Chloropyridin-3-Yl)-3-Oxopent-4-Enoate
CAS No.	1233055-23-6
Molecular Formula	C11H10ClNO3
Molecular Weight	239.65 g/mol
Synonyms	Methyl (2E)-5-(6-Chloro-3-pyridinyl)-3-oxo-4-pentenoate; (E)-Methyl 5-(6-Chloro-3-pyridinyl)-3-oxopent-4-enoate; 4-Pentenoic acid, 5-(6-chloro-3-pyridinyl)-3-oxo-, methyl ester, (E)-; Methyl 5-(6-chloropyridin-3-yl)-3-oxopent-4-enoate; (E)-5-(6-Chloropyridin-3-yl)-3-oxopent-4-enoic acid methyl ester
EINECS	Contact for details

Quality Control

Our (E)-Methyl 5-(6-Chloropyridin-3-Yl)-3-Oxopent-4-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can supply material compliant with various pharmacopeial standards (e.g., USP/EP) for development purposes upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.